Bloodstream viscosity and you can hypertension: role out of temperature and you will hyperglycemia

Yildirim Cinar, A. Mete Senyol, Kamber Duman, Blood viscosity and you may blood pressure levels: character regarding heat and you will hyperglycemia, American Journal out-of Blood pressure level, Frequency fourteen, Topic 5, , Profiles 433–438,

Abstract

We planned a study to research the relations among blood pressure (BP), viscosity, and temperature in healthy subjects and among BP, viscosity, and glucose in diabetics. With simple random sampling method, 53 healthy and 29 diabetes mellitus (DM) type II subjects were selected. Parameters were determined with capillary viscometer and glucometer at 22°C, 36.5°C, and 39.5°C in healthy subjects, and at 22°C on diabetic patients during OGTT with 75 g of glucose. Statistical evaluations of the data were made with regression analysis, Student t test, Spearman’s correlation, and analysis of variance. When temperature decreased from 36.5°C to 22°C, blood viscosity increased %. This increase resulted in a % decrease in blood flow rate. According to the Hagen-Poiseuille equation, the required BP increase for compensation of the resulting tissue ischemia was %. Also, a % decrease in erythrocyte deformability and % increase in plasma viscosity were seen. When temperature increased from 36.5° to 39.5°C, blood viscosity decreased %. This caused % decrease in blood flow rate, and % decrease in BP, according to the equation. Erythrocyte deformability increase of 9.92% and plasma viscosity decrease of 4.99% arose from the temperature rise. There is a correlation between total data for temperatures and viscosities (r = ?0.84, P < .001). When the mean value of blood glucose increased from 100 to 400 mg/dL, viscosity increased 25% (r = 0.59, P = .002). In this state, blood flow rate decrease was 20% and BP increase for physiological compensation was 25%. Consequently, temperature, glucose and viscosity levels of blood are important factors for BP. Am J Hypertens 2001;–438 © 2001 American Journal of Hypertension, Ltd.

The aim of our data should be to look into the dating certainly temperatures, sugar concentration, and you will viscosity regarding bloodstream and plasma, and to calculate their consequences to your blood pressure level (BP) predicated on Hagen-Poiseuille’s hydrodynamics formula.

If the human circulatory system is considered as a closed system, hemodynamic equilibrium can be determined according to Poiseuille’s equation through the pressure, viscosity, flow rate, velocity of blood, and vessel diameter. Viscosity can be defined as the resistance of fluids against flow. The resistance for blood circulation includes friction between the blood elements and between the vessel lumen and blood. To make a fluid flow, the application of energy is required. Therefore, the energy of the circulatory system is spent in correlation with the viscosity level of blood. Energy forms of the circulatory system are BP and blood flow velocity. The velocity (v) and pressure of blood flow can be determined with Poiseuille’s equation as v = 1/4?L (F₁ ? F₂) (a 2 ? r 2 ), and also BP rate (Q) can be expressed from the above equation as Q = ?a 4 /8 ?L (F₁ ? F₂), where ? is the viscosity of the fluid, F₁ and F₂ are the initial and the final cross sectional pressures of blood, L is the length, a is the radius of vessel, and r is the distance from the center of the vessel for a milf online flowing particle. 1, 2 Thus, to keep the equilibrium of the equation constant in the circulatory system, BP will increase when viscosity increases.

Blood viscosity and you may blood pressure levels: role away from temperatures and hyperglycemia

It’s been revealed that between % and you may % thinking out-of hematocrit, the eleven% upsurge in hematocrit develops bloodstream viscosity by the 20%. Within county, based on Poiseuille’s equation, blood circulation rate minimizes by the %, which may end up in structure ischemia. To save the latest circulatory system in harmony (which is, keeping the circulate rates sufficient and you will blocking tissue ischemia), a beneficial 20% boost in BP or 4.66% vasodilation is necessary. step 3 not, the human circulatory experience not an exact closed program, as blood viscosity will likely be altered towards intake out of food or medicines. 4–8 Concurrently, the effects out of fat molecules as well as specific medication with the bloodstream viscosity and hemodynamics such as for example BP have been advertised. While the atherosclerotic boats usually do not dilate sufficiently once the a response to vasodilator pills, this has been recommended one increased blood viscosity can simply be compensated with an effective BP rise in particularly affairs. 9–several As well as, the latest relationship certainly one of BP, headache, coagulation, blood circulation acceleration, and you will bloodstream viscosity was basically revealed via the prices out-of hemodynamics. 13, 14